My research focuses on various aspects of epigenetic mechanisms and pathways to revert the carcinogenesis using natural edible compounds. Triple Negative Breast Cancer is causing high mortalities among women in different ethnic groups. Therefore, my major focus is to investigate the molecular mechanisms which promote apoptosis through natural edibles. Currently my lab is characterizing few compounds along with some metal nanoparticles which promote apoptosis. The long term goal is to develop a good therapeutic molecule against Triple Negative Breast Cancer.
Besides, study of endangered animal habitats and survey is my curiosity.
General Publications
Publications: 57
Few are listed hereunder
- Myrna Hurtado, Laszlo Prokai, Umesh T. Sankpal, Blair Levesque, Rajasekhar Maram, Jaya Chhabra, Deondra T. Brown, Raj K Gurung, Alvin A. Holder, Jamboor K. Vishwanatha, Riyaz Basha. Next Generation sequencing and functional pathway analysis to understand the mechanism of action of copper-tolfenamic acid against pancreatic cancer cells, Process Biochemistry, Vol.89, pp: 155 – 164, February, 2020 https://doi.org/10.1016/j.procbio.2019.10.022
- Myrna Hurtado, Umesh T. Sankpal, Jaya Chhabra, Deondra T. Brown, Rajasekhar Maram, Rafid Patel, Raj K. Gurung, Jerry Simecka, Alvin A. Holder, Riyaz Basha. Copper-tolfenamic acid: evaluation of stability and anti-cancer activity. Investigational New Drugs. 2018. https://doi.org/10.1007/s10637-018-0594-9.
- Myrna Hurtado, Umesh T. Sankpal, Amalendu Ranjan, Rajasekhar Maram,Jamboor K. Vishwanatha, Ganji Purnachandra Nagaraju, Bassel F. El-Rayesc,, Riyaz Basha. Investigational agents to enhance the efficacy of chemotherapy or radiation in pancreatic cancer. Critical Reviews in Oncology / Hematology 126: 201–207, 2018
- Janardhana Rao, I.S.Chakrapani, M.Rajasekhar. Dwindling population of a Scincid Lizard Mabuya Carinata (SCHNEIDER, 1801) in Nellore District of Andhra Pradesh, South India. International Journal of Science and Research (IJSR), Vol.7, Issue 3, March 2018. https://www.ijsr.net/search_index_results_paperid.php?id=ART2018547,
- SaiKrishna Lakkakula, Ram Mohan P, Gyaneshwer Chaubey, Bhaskar Lakkakula, Rajasekhar M, Munirajan AK. NAT2 genetic variations among South Indian Populations. Human Genome Variation, Nature Publishing Group, 1, 14014. 2014.
- Jyotsna Murthy, Venkatesh Babu Gurramkonda, Saikrishna Lakkakula, Ram Mohan Pathapati, Rajasekhar M, Bhaskar Lakkakula VKS. Endothelial nitric oxide synthase VNTR (intron 4 a/b) polymorphism association with non syndromic oral clefts. Turk. J. Biochem, 38(3): 308-312, 2013.
- Chakrapani IS, Chanikyudu B, Janardhan Rao R, Rajasekahar M. Status Survey of the Indian Golden Gecko, Calodactylodes aureus (Beddome, 1970) in YSR Kadapa and SPSR Nellore Districts of Andhra Pradesh, India. World Journal of Zoology, 9(1): 21-27, 2014.
- Saikrishna Lakkakula, Rajasekhar M, Arasambattu Kannan Munirajan, Ram Mohan Pathapati, Subrahmanyam Battaramvisveswara, Bhaskar Lakkakula VKS. CYP1A1 gene IVS1-728G>A and Ile462Val polymorphisms in South Indian populations. J Cell Mol Biol, Halic University, Kağıthane, Istanbul, Turkey, 11(1&2): 67-75, 2013.
- Saikrishna Lakkakula, Rajasekhar M, Arasambattu Kannan Munirajan, Ram Mohan Pathapati, Subrahmanyam Bahattaramvisweswara and Bhaskar Lakkakula VKS. Functional PstI/RsaI Plymorphisms in the CYP2E1 Gene among South Indian Populations. Asian Pacific Journal of Cancer Prevention, 14: 179-182, 2013.
- Saikrishna Lakkakula, Rajasekhar M, Venkatesh Babu Gurramkonda, Ram Mohan Pathapati, Subrahmanyam Battaramvisweswara and Bhaskar Lakkakula VKS. Gene Frequencies of the Human GSTT1 (Null Allele) and GSTP1 (IIe105Val) Polymorphisms among South Indian Populations. Advances in Cancer Research and Treatment, Article ID:784869, 2013: 1-9, 2013.
Books
- G.Latha & Dr.M.Rajasekhar, Biomedical Waste Management in Hospitals, LULU publishers, USA, 2021
- M.Rajasekhar & I.S.Chakrapani, Herpetofauna of Seshachalam Hills, S.V. University Publication (Peer reviewed), 2014.
Research interest
Conferences Organized
International: 2
National: 2
Conferences attended and presented papers in India and Abroad: 38
Conferences attended and presented papers in USA:6
Research projects
Research Projects completed: 3
Ongoing: 1
Conference
- ICMR International Long term Foreign fellowship award for the year 2017 to Collaborate With UNTHSC, Fort Worth, Texas, USA , for 12 months.
- DST Young Scientist Award
- Young Scientist award in 3rd National Conference of National Environmentalists Association, held during 18-20 January 2009, Srikakulam, A.P.India
- Associate Fellow of Andhra Pradesh Akademi of Sciences, 2008
- Best Presentation award in National Seminar, Tanuku, 2006
- Senior Research Fellowship, World Bank Sponsored Project, 1998.
Dr. M.Rajasekhar has supervised seven Ph.ds and two M.Phils. He is curious in doing research on endangered animals like Golden geckos, Slender loris and Jordon’s Courser.
The first video filming by Dr. M. Rajasekhar on Jordon’s courser is a good contribution to the forest department which attracted several wildlife researchers to work on highly endangered bird. His research works on Golden Geckos were first of its kind in several locations of south India. Extensive survey reports revealed the status of this endemic and endangered gecko and helped Forest department to take measures to protect the animal.
The jungle Book theme park in Tirupati is also one among the good contributions to the society to develop ecotourism and also awareness on endangered animals in Seshachalam hills.
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